Prem S. Shekhawat, MBBS, MD, FAAP

Prem S. Shekhawat, MDProfessor of Pediatrics, Case Western Reserve University

Research Interests: My research interests include fetal-neonatal growth and metabolism and neonatal endocrinology with special emphasis on L-carnitine and fatty acid oxidation disorders as they relate to fetal growth and well-being. 

I also serve on the Editorial Boards of Journal of Neonatal-Perinatal Medicine, PLOS One, American Journal of Pediatrics, Journal of Neonatal Biology, 


1. “Safety of Furosemide in Premature Infants at Risk of Bronchopulmonary Dysplasia”. Protocol: NICHD-2014-FUR-01
Site Principal Investigator: Prem Shekhawat, MD
Agency: NICHD via Duke Clinical Research Institute (DCRI)
Amount: $ 98,000/year    December 2015 till January 2020.

2. “Multicenter double blinded randomized study of synthetic surfactant CHF 5633 in comparison to porcine surfactant Curosurf for RDS in preterm neonates. Protocol: CCD_5633AA1-02
Site Principal Investigator. 
Agency: Chiesi Farmaceutici S.p.A, Italy
Amount: $ 241,010 April 2016 till December 2017.

Published works in My Bibliography on National Library of Medicine: 

Selected Recent Publications: 

1. Kanike N, Groh-Wargo S, Thomas M, Chien EK, Mhanna M, Kumar D, Worley S, Singh RJ, Shekhawat PS. Risk of Iodine Deficiency in Extremely Low Gestational Age Newborns on Parenteral Nutrition. Nutrients. 2020 Jun 1;12(6):E1636. doi: 10.3390/nu12061636. 

2. Al-Jebawi, Y, Agrawal, N, Groh-Wargo, S, Shekhawat PS, Mhanna, MJ. Low caloric intake and high fluid intake during the first week of life are associated with the severity of bronchopulmonary dysplasia in extremely low birth weight infants. Journal of Neonatal-Perinatal Medicine 2020. DOI:10.3233/NPM-19026. 

3. Karsli T, Jain V, Mhanna M, Pepkowitz SH, Chandler DW, Wu Q, Shekhawat PS. Assessment of Adrenal function by profiling Adrenal Glucocorticoid precursors & their ratios using Tandem Mass Spectrometry. Pediatr Res. 2019 Oct 23. doi: 10.1038/s41390-019-0629-8. [Epub ahead of print]

4. Jain V*, Goel V*, Chowdhary V*, Swaroop N, Davis A, Singh R, Shekhawat PS. Anogenital distance is determined during early gestation in Human neonates. Human Reproduction, 2018 Sep 1;33(9):1619-1627. doi: 10.1093/humrep/dey265. 

5. Ravisankar S*, Tatum R, Garg P*, Herco MM, Shekhawat PS, Chen Y-H. Necrotizing Enterocolitis leads to disruption of tight junction proteins and increase in gut permeability in a mouse model. BMC Pediatrics 2018 Nov 27;18(1):372. doi: 10.1186/s12887-018-1346-x.

6. Shekhawat PS, Sonne S, Matern D, Ganapathy V. Embryonic lethality in mice due to carnitine transporter OCTN2 defect and placental carnitine deficiency. Placenta, 2018, Sep;69:71-73.