Deepak Kumar, MD

Professor, Pediatrics, Case Western Reserve University

Research Interests: Physiology of fetal membrane weakening specifically correlation of the mechanical properties of the fetal membranes with biochemical characteristics. Ultimate objective is to identify targets in mechanisms of fetal membrane weakening for therapeutic intervention to prevent preterm PROM related spontaneous preterm birth.  My additional interests include care of drug dependent mothers and their newborn infants, and Neonatal Nephrology with specific reference to Acute Kidney Injury.

Grants

2019-Present NIH. ACT NOW Randomized Blinded Trial to Shorten Pharmacologic Treatment of Newborns with Neonatal Opioid Withdrawal Syndrome (NOWS) (ACT NOW Weaning). (Co-PI; % time being determined). 09-2020-Present

2021 (Pending) NIH. Renal Injury Sequelae in NICU Graduates "ARISING (Pending Review)

2011-2017       March of Dimes – National #21-FY11-9, AND #21-FY15-124: Determination of the mechanism of preterm premature fetal membrane rupture using a novel in-vitro model system. Co-Investigator

2015-2019       Burroughs Wellcome Fund #1015024, Prematurity Research Grant, Co-Investigator. 

Published works in My Bibliography on National Library of Medicine: 
https://www.ncbi.nlm.nih.gov/myncbi/1vEQ5pRuUKbQ_P/bibliography/public/

Selected Recent Publications:

1. Raina R, Chakraborty R, Sethi SK, Kumar D, Gibson K, Bergmann C. Genetic and sporadic renal cystic diseases during the perinatal and neonatal period. 2021 Jul;78(1):125-141. doi: 10.1053/j.ajkd.2020.10.021. Epub 2021 Jan 6. Review. PubMed PMID: 33418012.

2. Kumar D, Moore RM, Mercer BM, Mansour JM, Moore JJ.  Mechanism of Human Fetal Membrane Biomechanical Weakening, Rupture and Potential Targets for Therapeutic Intervention. Obstet Gynecol Clin N Am. 2020 Dec;47(4):523-544. doi: 10.1016/j.ogc.2020.08.010. Review. PubMed PMID: 33121643.

3. Raina R, DeCoyc M, Chakrabortya R, Mahajan S, Moran R, Gibson K, Kumar D, Bergmann C. Renal cystic diseases during the perinatal and neonatal period. JNPM. 2020 (In Press) DOI:10.3233/NPM-200520

4. Pandey R, Kanike N, Ibrahim M, Swarup N, Super DM, Groh-Wargo S, Kumar D. Lactose-free infant formula does not change outcomes of neonatal abstinence syndrome (NAS): a randomized clinical trial. J Perinatol. J Perinatol. 2021 Mar;41(3):598-605. doi: 10.1038/s41372-020-00797-7. Epub 2020 Aug 31. PubMed PMID: 32868858.

5. Moore RM, Khatri R, Kumar D, Mansour JM, Mercer B, Moore JJ.  α-Lipoic acid blocks the GMCSF induced protease/protease inhibitor spectrum associated with fetal membrane weakening in-vitro. Placenta. 2020; 97:79-88.

6. Sinkey RG, Ozlem Guzeloglu-Kayisli, Sefa Arlier, Xiaofang Guo, Nihan Semerci, Robert Moore; Asli Ozmen, Kellie Larsen, Chinedu Nwabuobi, Deepak Kumar; John J. Moore; Lynn F. Buckwalder,  Frederick Schatz, Umit A. Kayisli,; Charles J. Lockwood. Thrombin-Induced Decidual Colony Stimulating Factor-2 (CSF-2) Promotes Abruption-Related Preterm Birth by Weakening Fetal Membranes. American Journal of Pathology. Am J Pathol. 2020 Feb;190(2):388-399.